Sarcouncil Journal of Multidisciplinary

Abstract: Epigenetic modifications are considered the primary and decisive factor in gene expression in reproduction. The main objective of this study was to determine the fertility-related outcomes for Iraqi patients and to identify the molecular pathways involved. Our methodology involved recruiting 97 patients from various hospitals in Baghdad, Iraq. The DNA homology patterns of 12 promoters associated with fertility and Demographic data from the patients were analyzed using IBM SPSS and Microsoft Excel. The results obtained in this study are: • (Age Fertile Group with 31.4 ± 4.7, Subfertile Group 33.8 ± 5.2) • FSH with G1 (6.8 ± 2.1) and G2 (9.4 ± 3.6) • AMH with G1 3.2 ± 1.4 and G2 (1.8 ± 1.1) with p-value <0.001* • Duration of infertility with a median of 28.0 • were upgraded H3K9me3, H3K27me3 in G 2 • H3K4me3, H4K16ac, H3K9ac, H3K27ac were diminished. • according to multivariable logistic regression were found HOXA10 promoter methylation with OR = 2.04; 95% CI In this study, we conclude that advances in molecular biology and genetics have shown that the physical and biological characteristics of individuals are not determined solely by genetic information, but also depend on how this information is expressed. Genes can be activated or repressed by epigenetic regulatory mechanisms influenced by the environment, and these mechanisms gain particular importance during embryonic development.