Sarcouncil Journal of Applied Sciences Aims & Scope

Abstract: Photoredox activation of latent C–H bonds is a premier strategy in contemporary organic synthesis, offering very selective and green access to carbon–carbon bond formation. Here, we report a methodological innovation in the activation of aliphatic C(sp³)–H bonds towards selective alkyl–alkyl cross-coupling under mild, green reaction conditions with the assistance of visible-light irradiation and green solvent systems. The approach relies on generating carbon-centered radicals by hydrogen atom transfer (HAT) or single-electron transfer (SET) reactions followed by transition-metal-catalyzed (Ni or Cu) coupling to offer chemo- and regioselective control. Substrate scope is represented by benzylic, allylic, and unactivated aliphatic systems, with attendant potential for applications in pharmaceuticals, agrochemicals, and advanced materials synthesis. This method cuts chemical waste in half and energy consumption by up to 80% compared to standard procedures, and is aligned with green chemistry principles. Integration with continuous-flow photoreactor platforms optimizes scalability and user-friendliness, enabling industrial-scale application.