Abstract

In this study, 80 patients were collected from several different hospitals in Iraq and aimed to exploring the underlying mechanisms that lead to the development and progression of rheumatologic diseases at the cellular and molecular levels. The most prevalent chronic illness in humans and a leading source of lifelong impairment, rheumatic illnesses, are complex conditions that are better understood using molecular genetic techniques in rheumatology. They pinpoint possible infectious causes, with genetic traits impacting disease determinants on an individual basis. Understanding illness causation, severity analysis, therapy selection, and patient data categorization are all improved by researching gene heterogeneity. The clinical and pathological characteristics of rheumatic diseases include heterogeneity tendency to progression. The heterogeneity of the nature of rheumatic diseases is determined by the multifactorial nature of the diseases when certain combinations of environmental factors and polygenic backgrounds influence not only the susceptibility to the disease but also its severity and outcome. Understanding of the molecular genetic complexity and complexity of these disorders is incomplete, and there are currently no criteria for forming patient subgroups for differential treatment. We conclude from this study that the use of genetic analysis methods with microbiological, immunological, and other laboratory diagnostic methods has made it possible to show that the microbial factor and the genetic characteristics of the individual play an important role in the development of rheumatic diseases

Keywords

Pathophysiology, Genetic, Multifactorial, Molecular, Heterogeneity, Patients