Abstract

Background: Growth Hormone (GH) and Insulin-like Growth Factor (IGF-1) stimulate proliferation, differentiation and extracellular matrix production in osteoblastic cells.GH and IGF-1 also stimulate recruitment and bone resorption activity in osteoclasticcells. A chronic systemic GH and IGF-1 excess produces an increased bone turn over in acromegaly patients (pts).Osteoporosis, joint alterations and bone deformities have a great clinical relevance in acromegaly patients and favor mortality and morbidity. In the present study we evaluate the stillunclear GH/IGF-1 activity on bone, Bone Mineral Density (BMD) and risk of osteoporotic  Fractures , in relation to several Pt’s variables in acromegaly patients.The present study examines 61 acromegaly patients with different age group and different variables and study their DEXA scan findings of them.Objective of the study: searching for DEXA scan findings in a group of acromegaly patients attending regularly the national center of diabetes at al- Yarmouk teaching hospital on a basis of scheduled appointments. Patients and Methods: this is a prospective cohort study of 61 patients attending the national center of diabetes at al-Yarmouk teaching hospital regularly on the basis of regular appointments from June 2016 to April 2017.Results : For the 61 patients ,  41 Males(67.2%) ,20 Females ( 32.8%) were chosen randomly and the age group between ( 24 – 68) years, 24 patients had osteopenia at spine Z-score, 5 patients shows osteoporosis, 23 patients had osteopenia at sine T-score. 19 patients had osteopenia at total hip Z-score, 7 patients had osteoporosis, 17 patients had osteopenia at total hip T-score. 3 patients had osteoporosis, 16 patients had osteopenia at intertrochanteric Z-score, 6 patients had osteoporosis, 18 patients had osteopenia at intertrochanteric T-score. In these patients the 10 years probability of fractures in different fracture type as follow:  In Osteoporotic type with BMD the mean and SD was (3.73±0.57) %, range (2.12%-4.93%). In osteoporotic without BMD the mean and SD was (3.04±0.27)%, range was (2.10-3.64)%. In Hip fracture type with BMD the mean and SD was (0.55±0.57)%, and range was (0.01-1.9)%. In Hip fracture type without BMD the mean and SD was (0.27±0.18)%, their range was (0.10-0.80)%

Keywords

BMD, SD, HIP FRACTURE