Abstract

BACKGROUND: pyridoxine (vitamin B6) is a dietary supplement that is used effectively in the treatment of pregnancy-associated nausea and vomiting but its role in the management of postoperative nausea and vomiting is not clearly understood. METHODS: We conduct a randomized controlled prospective trial to measure the effect of intravenous pyridoxine on the incidence of postoperative nausea and vomiting in the early postoperative period (24 hours) in parturients undergoing elective caesarian section under general anesthesia. 85 pregnant women were enrolled in the study, after the application of exclusion criteria which were a previous history of postoperative nausea and vomiting, and a history of motion sickness; 70 women were included in the effective data analysis, 35 women received intraoperative pyridoxine (group P.) and the other 35 women received placebo intraoperatively (group C). RESULTS: we did not notice a difference in the incidence of postoperative nausea and vomiting between group P and group C. CONCLUSION: administration of intravenous pyridoxine has no effect on the incidence of nausea and vomiting in the early postoperative period of women undergoing elective caesarian section under general anesthesia

Keywords

pyridoxine, postoperative nausea and vomiting, cesarean section, antiemetic prophylaxis