Sarcouncil Journal of Medical Series

Abstract: We present two cases diagnosed with PGNMID post-transplant. The first case is that of a 42 year old lady who was diagnosed as chronic glomerulonephritis with MPGN pattern of injury, the aetiology of which wasn’t identified despite two native kidney biopsies. Her immunofluorescence in both biopsies was incomplete. She progressed to end stage renal disease and underwent a cadaver transplant. Four months post transplant she developed allograft dysfunction and was diagnosed with PGNMID after two allograft biopsies. Despite chemotherapy her renal functions worsened and was reinitiated on dialysis. The second case is that of a 59 year old lady who was transplanted in 2001 and was stable until 2020. She developed allograft dysfunction with proteinuria and her allograft biopsy showed mesangial and endocapillary proliferation with kappa light chain restriction clinching the diagnosis of PGNMID which was denovo post-transplant eventually resulting in graft loss