Abstract
Changes in lipid profile during pregnancy has being normally observed and these changes mostly differ according to trimester. An increased maternal morbidity and mortality was recorded in history due to severe or uncontrolled Gestational hypertension (GH) and leads to more than 14% of early or preterm births. During pregnancy, its documented that Dyslipidaemia hyperuricemia are strongly believed to have pathophysiological role. A total of 150 women among which 100 pregnant women and 50 non pregnant women have participated in the study. Serum T. cholesterol (TC), triacylglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were tested and estimated in the study. It was found in this study that Total cholesterol, triglycerides and high density lipoprotein in the three trimesters when compared to the control subjects were found to be high (p< 0.05). The change inlow density lipoprotein was not significantly high (p> 0.05) in the first trimester but becamesignificant (p< 0.05) in the second and third trimester when compared with the control. Comparison between first, second and third trimesters showed that TC, TG and LDL in the 2ndand 3rd trimesters were significantly higher than in the 1st trimester. Serum uric acid Serum lipid profile were analysed and estimated by enzymatic methods. The serum uric acid showed was found to be strongly correlated with systolic blood pressure, TGL (r = 0.293, p < 0.01;) TGL/HDL (r = 0.549, p < 0.001; r = 0.434, p < 0.001 respectively) and a negative correlation with HDL/VLDL (r = -0.423, p < 0.001). Triglyceride showed significant positive relation with diastolic blood pressure (r = 323, p = 0.001); uric acid (r = 0.553, p < 0.001), TGL/HDL (r = 0.759, p < 0.001) and negative relation with HDL/VLDL (r=0.691, p < 0.001). In the early 2nd trimester, estimation of lipid profile and serum uric acid can be advisable to prevent complications of Gestational Hypertension.
Keywords
Pregnancy, Lipid Uric acid