Abstract

In present era, research work has the continuous focus on the formulation development of chitosan coated flexible liposomes (chitosomes) of Mupirocin that has persistent mitigation of laceration. Skin injuries also known as Lacerations that need proper management to avoid serious consequences in terms of morbidity, disability and quality of life. Currently, the focus of wound management is to maintain the water balance of the wound bed and prevent the invasion of pathogens. Wound dressings in the form of flexible liposomes containing antimicrobial agents (mupirocin) can be used to control skin infections. The drug in the flexible liposome can also extend the contact time between the drug and the wound area, thus reducing the need for frequent use of wound dressings. Human skin is the largest organ in the human body, with a surface area of ​​100 cm2.can effectively use for the drug delivery. Our project aims to develop the chitosomes of Mupirocin using soya lecithin and edge activator. Mupirocin was analyzed through physio-chemical and analytical parameters like pre-formulation studies, melting point, solubility, calibration curve, FTIR. The drug excipient compatibility study was also conducted. The chitosomes were prepared by Rota evaporator technique with a dose 100mg per 50 ml. The chitosan coated flexible liposomes were evaluated by various parameters like particle size, polydispersity index, percentage yield, encapsulation efficiency, %dug content and in vitro drug release studies. The stability study for all formulations were conducted for 2 months and found to be satisfactory as per requirement

Keywords

Chitosan coated flexible liposomes, Laceration, Mupirocin, Wound healing