Sarcouncil Journal of Medical Sciences

Abstract: It is multidisciplinary in nature because of the overlap between the Hematology, rheumatology, and rehabilitation fields. Purpose: The current review attempts to provide an extensive account of Felty syndrome, especially concerning its pathophysiology, diagnostic principles, and treatment plans. Methods: A systematic literature search was conducted, the focus of which was the key etiological processes of Felty syndrome, the diagnostic criteria, and the treatment options, which include disease-modifying antirheumatic drugs (DMARDs), granulocyte colony-stimulating factors (G-CSF), and rehabilitative interventions. Findings: Splenic sequestration, immune-mediated cytopenia, and neutrophil production dysfunction are the pathophysiology of Felty syndrome where Strong control of RA, the judicious choice of immunosuppressive agents and their application based on the risk of infection, and the individualized rehabilitation programs to improve the functional capacity and quality of life all should be required to manage the disease effectively as well as that the holistic approach to the treatment of Felty syndrome should include a team of haematologists, rheumatologists, and rehabilitation professionals. Future studies must focus on the idea of precision medicine to optimize treatment and improve the outcomes of people with the disorder. Continuous education and support to patients are inalienable in the engagement and safety in the treatment of this multifaceted condition.