Sarcouncil Journal of Biomedical Sciences

Abstract: Quantitative abnormalities were defined as significant factors in the diagnosis of infertility among Iraqi patients included in our current study. The main objective of this study was to identify and evaluate the outcomes associated with chromosomal abnormalities and their impact on patients with infertility. A total of 123 patients were included in the study period from 2023 to 2026. The methodology of this study relied on conventional karyotype analysis using G banding with FISH activation. All data and demographic information were extracted using IBM SOFT SPSS statistical analysis software. The results found in this study are chromosomal abnormalities were identified in 39 of the 123 patients; structural abnormalities in 9.8%; exogenous chromosome-specific anomalies in 4.9%; Klinefelter syndrome (47, XXY) in males (4.9%); mosaicism syndrome (45, X/46, XX) in females (3.3%); and duration of infertility. (6.5 ± 3.4 vs. 3.8 ± 2.6 years; p < 0.001), Logistic regression analysis of sex chromosome abnormalities OR = 12.02; 95% CI: 4.30–33.58; p < 0.001 where finally we conclouded A significant proportion of cases of infertility are due to chromosomal abnormalities, and the reproductive outcomes are significantly poorer.