Sarcouncil Journal of Biomedical Sciences

Abstract: In this study, five sulfonamide derivatives 7a1, 7a2, 7a3, 7a4, and 7a5, were successfully synthesized from nitrovanillin as the starting material using simple and efficient methods through six reaction stages. Among these synthesis stages, two steps were assisted by microwave irradiation, which significantly reduced the reaction time and improved the yield compared to traditional organic synthesis methods. The structures of the five sulfonamides were accurately determined using modern spectroscopic techniques, including NMR and MS.