Sarcouncil Journal of Medicine and Surgery

Abstract: Background: Appendicitis is the most prevalent reason for acute abdominal discomfort needing surgical intervention. It's unclear causing appendicitis. The pathogenic mechanism is still under debate. Even with improvements in asepsis and surgical methods, postoperative complications such as wound infection as well as intra-abdominal abscess continue to be an important factor of morbidity. Multiple studies indicate that following surgery. Antimicrobial regimens are used to minimize infections. Aim of study: This review investigated the use in preoperative antibiotics relative to no antibiotics for patients undergoing appendectomy in acute appendicitis. Methods: This is retrospective cohort study which was carried out on (100) patients in al Yarmouk teaching hospital where the patients divided into groups for each group (50) patients, both group where compared on antibiotic administration pre-operative and relation of wound infection post – operative where appendix that present at time of operation as (normal, actually inflamed or complicated as perforated or gangrenous) where test group received antibiotic. Result: The study group was composed of (54 % female) & (46 % male), among the control gr. (n = 50) pt. There were 14 (28 %) pt. had wound infection & test gr. (n = 50) pt. has 6 (12 %) had wound infection. There is a statically significant association of actually inflamed appendicitis between the control & test gr. (p = 0.023) whereas there is no significant association between normal & complicated appendix on both control & test gr. (p = 0. 33, p = 0. 75) respectively. There is a risk of developing wound infection among the control gr. Who had an inflamed appendix are 5.73, where the number of cases is 100. Conclusion: 1. Prophylactic I.V. Metronidazole can decrease wound infection significantly among patients underwent appendectomy, especially in cases with an actually inflamed appendix. 2. Wound infection in patients who underwent appendectomy with a normal appendix, as well as complicated (perforated or gangrenous), and take i. v Metronidazole shows no significant difference from those who did not take it.