Sarcouncil Journal of Medical Sciences

Abstract: Background can defined Pemphigus gravidarum, also known as pemphigoid Gestationis, is a rare autoimmune blistering disorder occurring during pregnancy, associated with significant maternal and fetal complications which Despite its clinical importance, comprehensive synthesis of existing evidence on its complications and management remains limited and aim of study was This meta-analysis aims to evaluate the spectrum of maternal and fetal complications in patients with pemphigus gravidarum, assess treatment outcomes, and provide evidence-based clinical recommendations as well as Methods can be defines A systematic review and meta-analysis were conducted including nine studies published between 2005 and 2025 as well as Data on study design, sample characteristics, clinical outcomes, and treatment modalities were extracted and synthesized with Quantitative and qualitative analyses were performed to assess pregnancy outcomes, disease course, and therapeutic efficacy. The Results which found were the analysis revealed that pemphigus gravidarum is associated with increased risks of preterm delivery, intrauterine growth restriction, low birth weight, and neonatal pemphigoid in a subset of cases in addition to Systemic corticosteroids were the predominant treatment, demonstrating efficacy in controlling maternal disease activity and improving pregnancy outcomes also in study Disease flares were common during early pregnancy and postpartum. Multidisciplinary management and early intervention were identified as key factors in optimizing maternal and neonatal health. Finally, in our meta-analysis, Pemphigus gravidarum poses considerable risks during pregnancy but can be effectively managed with timely diagnosis and appropriate therapy.