Abstract

A cross-sectional study was conducted in different hospitals in Iraq, involving 110 cases from various hospitals, with the objective of diagnosing autoimmune disorders and their impact on fertility in Iraqi women from March 2023 to February 2024. The study employed a descriptive approach to assess the impact of treatment on women and identify any negative effects after pregnancy. A questionnaire comprising 50 items was distributed to patients, covering personal information, primary immunodeficiency diseases, family experiences, perceptions of fertility and childbirth, and the influence of immunodeficiency on pregnancy -decisions. Data was analysed using Microsoft Excel, Microsoft Access, and SPSS. A higher prevalence of autoimmune diseases is noted among women compared to men, with more than 85% of all patients suffering from multiple such conditions being female. Women experience two intense endocrine changes in their lives: puberty and menopause. Most women also go through a transition period, possibly involving pregnancy or breastfeeding that sometimes lasts months or years. The immune system changes by the endocrine are important to modifying vulnerability in women, as these changes involve numerous hormonal milieu interactions and their pathways between the innate and acquired immune response mechanisms. So, human resistivity to autoimmune diseases is altered. Again, certain pre-existing autoimmune conditions can also alter them. It affects the immunity system by estrogen-dependent concentration