Sarcouncil Journal of Internal Medicine and Public Health

Abstract: We read with interest the article by Alenezi, et al. about a 28yo female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome due to the variant m.3243A>G in MT-TL1 who manifested with the classical phenotypic features of the mtDNA variant, including a status epileptics [Alenezi, A. F. et al., 2022]. It was concluded that status epilepticus should be considered as a manifestation of MELAS in young females with a history of stroke-like episodes (SLEs) [Alenezi, A. F. et al., 2022]. The study is appealing but raises concerns that should be discussed.