Abstract

Background: Down syndrome is a genetic condition brought on by the existence of a third copy of chromosome 2 1 in whole or in part. Even though, it is frequently linked to mild to severe physical growth delays and distinctive facial traits. However, some students in Rome receive their education in regular schools, others need a more specialized education where some people with DS complete their high school education where a small number continue their education after that. Objective: This paper aims to conduct a cross-sectional study in Iraq to know the outcomes of lipid profiles in patients with Down syndrome of children. Patients and Methods: Data were collected retrospectively through reviews of electronic medical records or electronic hospital records, and discharge data for all Down syndrome patients from different hospitals in Iraq between 3^rd Jun 2021 to 7^th July 2022, who were children among all patients who underwent procedures. These data were designed with two groups where the first group was represented with Down syndrome patients who have 40 patients while the second group represented control who contain 30. A statistical study was conducted for patients using the SPSS program. Discussion: The study includes 40 Down syndrome patients between the ages of 5 and 10 years, with 8.5±2.5 of the control group. Data on the distribution of patients’ indicator values in obese 7 (17.5 %) for Down syndrome patients while 6 (20 %) for the control and overweight child ren for Down syndrome patients 15 (37.5 %) while 3 (I0 %) for the control group are presented in this study. As well as this study was found an increase of patients’ hypertension 5 (12.5 %) for Down syndrome patients and 3 (10 %) for the control group. Obesity and being overweight  do  not appear to significantly increase the risk of cardiometabolic disease. Although ApoA-physiological I’s anti-atherosclerotic activities are widely known, ApoA-function II’s is still not completely understood. According to certain research, elevated ApoA-II reduces reverse cholesterol transport and HDL’s antioxidant capacity, which in turn encourages atherosclerosis. Conclusions: According to the results of the study, TC, TG, and LDL increased significantly while HDL decreased significantly in DS. The results indicated that children with Down syndrome had unfavorable lipid profiles, particularly an increase in Lp (a) levels, as well as a change in the quality of high-density lipoprotein cholesterol, compared to the control group.

Keywords

Down’s syndrome; Obesity; Hyperlipidaemia; Hypertension; and QOL