Abstract

The genetic causes of infertility in women are almost completely unknown. One of the genes associated with a higher risk of female infertility is the human progesterone receptor gene. Multiple polymorphisms have been discovered in this gene; however, PROGINS stands out as a variation with a 306-bp Alu-insertion in intron G and two-factor mutations in exon 4 and 5 (V660L and H770H, respectively), which both occur in the PGR polymorphism. For the purpose of determining the prevalence and pattern of the PROGINS 306 bp Alu insertion in intron G polymorphism in Iraqi women with unexplained infertility, it was an associated risk factor; we are doing this research. PGR gene polymorphism (Alu insertion in intron G) was evaluated in 70 patients with idiopathic infertility and 60 healthy fertile women as controls in this research, which looked at the genotype frequency polymorphism of PROGINs. According to the findings, the proportion of patients with unexplained infertility who had polymorphism genotypes (G1/G2 and G2/G2) was substantially greater than that of the control group (33%). (16 percent ) We find that the PROGINS polymorphism of the PGR gene has a strong link with unexplained infertility in Iraqi women

Keywords

PGR, gene, PROGINS, Estrogen, hormones, pregnancy, Iraq