Abstract
Background: One of the uncommon infectious organisms, Helicobacter pylori (HP), causes several gastroduodenal illnesses, including chronic gastritis, duodenal ulcers, as well as adenocarcinoma. Objective: Our study aims to assess the outcomes of H. pylori in children with Celiac disease. Patients and methods: This paper was aimed to assess the outcomes of H. pylori in Iraqi children with Celiac disease for 80 cases, which have included two groups. Where the first group was the patients’ group (patients with Celiac disease), with 40 cases, while the second group was the control group (patients without Celiac disease), with 40 cases, the databases of outcomes were conducted at the different hospitals in Iraq, which organized between 16th July 2021 to 25th August 2022. The methodology of databases was analysed and extracted by the SPSS program. Discussion: In line with prior research, we discovered small, non-significant variations in the blood levels of IgA-tTG in individuals who tested positive of H. pylori in comparison to those who did not. In contrast to children who tested negative for H. pylori, some of the latter we have had a slight rise in IgA-AGA levels. Regarding histological changes, we discovered that, in comparison to patients who were negative for H. pylori and displayed more severe intestinal damage, including complete villous atrophy, a greater proportion of CD patients had milder forms of enteropathy. Conclusion: In conclusion, the connection between stomach HP infection and celiac disease (CD) is inverse, proving that HP does not constitute a risk factor for CD. Additional research is needed to validate the conflicting evidence on the link between HP infection and celiac disease (CD).
Keywords
Celiac disease (CD); Endomysium antibody level (EMA); Helicobacter pylor (HP); and Doku-transglutaminase antibody level (DTG).